Frank Sönnichsen,  Prof. Dr. rer. nat. 

FSoennichsen@oc.uni-kiel.de

apl. Professor für Organische Chemie

Leiter der Spektroskopie

Adj. Associate Professor für Physiology und Biophysik @ Case Western Reserve University

Adresse:

Otto Hahn Platz 5
D-24098 Kiel
Germany
Tel.: +49-(0)431-880-2455
EMail: fsoennichsen@oc.uni-kiel.de

fdsoennichsen

Kurzbiographie :



Ausbildung

1989
Dr. rer.nat in Organischer Chemie
Nebenfächer Physikalische Chemie und Toxikologie
Christian-Albrechts-Universität
Kiel


1985
Diplom (“Master's”) in Chemie
Christian-Albrechts-Universität
Kiel


1982
Vordiplom (“Bachelor's Degree”) in Chemie
Christian-Albrechts-Universität
Kiel,

Positionen

seit 2010
apl. Professor für Organische Chemie, CAU Kiel

seit 2008
Leiter der Spektroskopie, Organische Chemie, CAU Kiel

2002 - 2007
Associate Professor
Department of Physiology and Biophysics
Case Western Reserve Universität, Cleveland, Ohio, USA

2000-2007
Director of NMR facilities
Cleveland Center for Structural Biology, Cleveland, Ohio, USA

1995 - 2002
Assistant Professor
Department of Physiology and Biophysics
Case Western Reserve Universität, Cleveland, Ohio, USA

1992 - 1995
Research Associate
Protein Engineering Network Centres of Excellence
University of Alberta, Edmonton Alberta, Canada

1989 - 1992
Post-doctoral Fellow with Professor Brian Sykes
Department of Biochemistry
University of Alberta, Edmonton Alberta, Canada

Ausgewählte Publikationen:

  • F.D. Sönnichsen, H.L. Chao, P.L. Davies, B.D. Sykes, ‘The Nonhelical Structure of Type III Antifreeze Protein’, Science 259, 1154-1157 (1993).
  • F.D. Sönnichsen, C.I. DeLuca, P.L. Davies, B.D. Sykes, ‘Refined solution structure of Type III Antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction’, Structure 4 (15), 1325-1337 (1996).
  • N.J. Cobb, FD Sönnichsen, H. Mchaourab, W.K. Surewicz, 'Molecular architecture of human prion protein amyloid, Proc. Nat. Acad Sci., 104, 18946-18951 (2007).
  • W.D. Van Horn, H-K Kim, C.D. Ellis, A. Hadziselimovic, E.S. Sulistijo, M.D. Karra, C Tian, F.D. Sönnichsen, CR Sanders, Solution NMR Structure of the Membrane-integral DAGK Kinase, Science 324, 1726-1729 (2009).
  • S. Venkataramani, U. Jana, M. Dommaschk, F.D. Sönnichsen, F. Tuczek, R. Herges, Magnetic Bistability of Molecules in Homogeneous Solutions at Room Temperature’, Science 331, 445-448 (2011).
  • S. Jung, F. D. Sönnichsen, C. Hung, C. Boidin-Wichlacz, C. Gelhaus, M. Leippe, A. Tasiemski, R. Podschun, A. Tholey, J. Grötzinger, ’Macin Family of Antimicrobial Proteins combines antimicrobial and nerve repair activities’, J Biol Chem. 287, 14246-14258 (2012).
  • M. Michalek, F.D. Sönnichsen, R. Wechselberger, A.J. Dingley, Chien-Wen Hung, A. Kopp, H. Wienk, Maren Simanski, R. Herbst, I. Lorenzen, F. Marciano-Cabral, C. Gelhaus, T. Gutsmann, A. Tholey, J. Grötzinger, M. Leippe, New toxin from the soil: Structure and function of a unique pore-forming protein from a free-living amoeba and human pathogen, Nature Chem Biol. 9 , 37-42 (2013).
  • P. J. Barrett, J. Chen, M.K. Cho, J.H Kim, Z. Lu, S. Mathew, D. Peng, Y. Song, W.D. Van Horn, T. Shuang, C.R. Sanders, “The Quiet Renaissance of Protein Nuclear Magnetic Resonance’, Biochemistry 52, 1303-1320 (2013).
  • S. Düsterhöft, S. Jung, CW Hung, A Tholey, F.D. Sönnichsen, J. Grötzinger, , I. Lorenzen ‘The membrane-proximal domain of ADAM17 represents the putative molecular switch of its activity operated by Protein-disulfide isomerase. J. Amer. Chem. Soc 135, 5776–5781 (2013).
  • F. Westphal, F.D. Sönnichsen, S. Knecht, V. Auwärter, L. Huppertz, ‚‘Two thiasolylindoles and a benzimidazole: Novel compounds on the designer drug market with potential cannabinoid receptor activity‘, Forensic Science International 249, 133-147 (2015).
  • . M. Michalek, S. Jung, M.R. Shomali, S. Cauchard, F.D. Sönnichsen, J. Grötzinger ‚‘Solution structure and functional studies of the highly potent equine antimicrobial peptide DEFA1‘, Biochem Biophys Res Comm 459, 668-672 (2015).
  • A. Müller, H. Kobarg, V. Chandrasekaran, J.Gronow, F.D. Sönnichsen, T.K. Lindhorst, ‚Synthesis of bifunctional glycoconjugates for Cysteine-based photosensitive Cross-linking with bioactive peptides, Chemistry 21, 13723-13731 (2015).
  • J. Strüben, M. Lipfert, J.O. Springer, C.A. Gould, P.J. Gates, F.D. Sönnichsen, A.Staubitz ‚High-yield lithiatioation of azobenzenes by tin-lithium exchange‘, Chemistry 27, 11165-11173 (2015).
  • M. Dommaschk, M. Peters, f. Gutzeit, C. Schütt, C. Näther, F.D. Sönnichsen, S. Tiwari, C. Riedel, S. Boretius, R. Herges, ‚Photoswitchable magnetic resonance imaging contrast by improved light-driven coordination-induced spin state switch, J. Amer. Chem. Soc 137, 7552-7555 (2015).
  • H. Krudopp, F.D. Sönnichsen, A. Steffen-Heins, ‚Partitioning of nitroxides in dispersed systems investigated by ultrafiltration, EPR and NMR spectroscopy‘, J. Colloid Interfac Sci 452, 15-23 (2015).
  • Jung S, Fischer J, Spudy B, Kerkow T, Sönnichsen FD, Xue L, Bonvin AM, Goettig P, Magdolen V, Meyer-Hoffert U, Grötzinger J., The solution structure of the kallikreinin-related peptidases inhibitor SPINK6, Biochem. Biophys. Res. Commun. 47, 103-108 (2016).
  • A. Sommer, F. Kordowski, J. Büch, T. Maretzky, A. Evers, J. Andrä, S. Düsterhöft, M. Michalek, I. Lorenzen, P. Somasundaram, A. Tholey, F.D. Sönnichsen, K. Kunzelmann, C. Nehls, L. Heinbockel, T. Gutsmann, J. Grötzinger, S. Bhakdi, and K. Reiss, ‘Phosphatidylserine exposure is required for ADAM17 sheddase function’, Nature Comm. In press (2016).

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    Englische Version

    © Frank Sönnichsen
    26.10.2017

    Otto-Hahn-Platz 4
    D-24098 Kiel

    Büro: Raum 222
    Tel: +49 (0)431 880-1540
    Fax: +49 (0)431 880-1558