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Lindhorst Group
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Fresh from the press:
Orthogonal photoswitching of heterobivalent azobenzene glycoclusters: The effect of glycoligand orientation in bacterial adhesion, Leon Merten Friedrich, Thisbe K. Lindhorst, Beilstein J. Org. Chem. 2025, 21, 736-748, doi:10.3762/bjoc.21.57, open access.
Lectin-mediated adhesion: Testing of tailor-made cellulose derivatives with ConA and live E. coli bacteria, Carina Spormann*, Tobias Dorn, Stefan Schwaiger, Sönke Sdunnus, Andreas Koschella, Hanspeter Kählig, Thomas Heinze, Thisbe K. Lindhorst*, Tanja M. Wrodnigg,* Bioorg. Med. Chem. 2025, 127, 118236, doi.org/10.1016/j.bmc.2025.118236.
Regioisomeric Branched Trisaccharides: A Combined Synthetic, Biological, and Computational Approach to Understand Details of FimH-Mediated Bacterial Adhesion, Ingo vom Sondern, Thisbe K. Lindhorst, Org. Biomol. Chem. 2025, doi.org/10.1039/D5OB00927H, open access.
Bivalent Inhibitors of Mannose-specific Bacterial Adhesion: A Xylose-based Conformational Switch to Control Glycoligand Distance, Sven Ole Jaeschke, Ingo vom Sondern, Thisbe K. Lindhorst, Molecules 2025, 30, 3074, doi: 10.3390/molecules30153074, open access.
Advancing Optoglycomics: Two Orthogonal Azobenzene Glycoside Antennas in One Glycocluster – Synthesis, Switching Cycles, Kinetics and Molecular Dynamics
Leon M. Friedrich, B. Hartke, Thisbe K. Lindhorst
Chem. Eur. J. 2024, e202402125, doi.org/10.1002/chem.202402125, open access.
Ready chemistry with a rare sugar: Altrobioside synthesis and analysis of conformational
characteristics
Clemens Lütjohann, Christian Näther, Thisbe K. Lindhorst
Carbohydr. Res. 2024, doi.org/10.1016/j.carres.2024.109228, open access.
Trivalent Heteroglycoclusters as Focal Point Pseudoenantiomers: Synthesis and Preliminary Biological Evaluation
Guillaume Despras, Carina Spormann, Felix Klockmann, Dieter Schollmeyer, Andreas Terfort, Thisbe K. Lindhorst
Eur. J. Org. Chem. 2024, e20240080, doi.org/10.1002/ejoc.202400809, open access.
Migration of para-Nitrophenyl Groups in Methyl Pyranosides: Configuration and Conformation Determine the Kinetic Dynamics
Leon M. Friedrich,* Clemens Lütjohann,* Bernd Hartke, Thisbe K. Lindhorst*
Chem. Eur. J. 2024, e20240311, doi.org/10.1002/chem.202403117, (inside cover).
Biological
Chemisty of Carbohydrates and Glycoconjugates - Carbohydrate, Peptide, Dendrimer
Synthesis - Ligand-Receptor Interactions - Conformational Control - Conformational Switches - Photoaffinity
Labeling - Ligand Design - Molecular Modeling - Bacterial Adhesion to the Glycocalyx
- Organizing Multivalency Effects - Molecular Diversity - Lectin Binding
Review: Organizing multivalency in carbohydrate recognition Download
Review: Oligosaccharides and glycoconjugates in recognition processes DownloadOur Research is Concerned with
(A chapter in: Handbook of Carbohydrate-Modifying Biocatalysts, P. Grunwald (Ed.), Pan Stanford Publishing Ltd., 2016, 2nd edition, pp 147-215; ISBN 978-981-4669-788.